What are fibroblasts and what are the advantages of bioprinting fibroblasts?
Have you ever imagined a world where doctors and scientists could use a special printer to create new skin-like tissues? Well, that future is here! Picture this: cells called human dermal fibroblasts and our Claro™® GelMA coming together in a 3D printer to build structures that mimic skin.
Tissue engineering: the ultimate solution to regenerate human tissue
Restoring What's Lost: Tissue Engineering for a Brighter Future Human tissue loss can occur at any point in our lives due to various reasons such as vascular diseases, sudden trauma, or cancer. Vascular diseases encompass conditions like diabetes, peripheral arterial disease (PAD), and blood clots, which can impede blood flow to limbs and result in...
Claro has now joined forces with Regemat 3D (a biotech company pioneer in the design and development of customized 3D bioprinters and bioreactors for research in the regenerative medicine field), which will now distribute Claro’s BG800 that was developed for extrusion-based bioprinters.
Claro acknowledges that bioprinting will help periodontal therapy advance
Periodontal (gum) disease: an annual cost estimated at 79 billion euros in Europe Periodontal (gum) disease is extremely common. Severe periodontal diseases are found in 5–20% of middle-aged (35–44 years) adults in Europe, and up to 40% of older people (65–74 years). Diseases of the mouth are an expensive burden to health care services.
GelMA by Claro: great potential to build 3D models that mimic real tumors
The need for innovative 3D cancer models to enhance drug-testing process The National Cancer Institute defines cancer as “a term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems.” [1]. Metastases are the primary...
The technology Gelatin methacryloyl (GelMA) hydrogels demonstrate a well-recognized cytocompatible behavior [1] and therefore, are ideal when developing bio-inks for engineering connective, epithelial, muscle, and nervous tissues. However, high printing pressures and ultimately nozzle blockages are recurrent issues when bioprinting with GelMA.
Gelation temperature (Tgel) and printing settings (e.g. printing speed and nozzle gauge) are influenced by two controllable variables: gelatin methacryloyl (GelMA) concentration and the degree of functionalization (DoF). Higher hydrogel concentrations combined with low DoF will result in higher Tgel. Thermo-sensitive materials, such as GelMA...
Bioinks for extrusion-based printing need flow during the extrusion phase and should have shape-retention after the deposition of the filament. This behavior can be evaluated by two rheological parameters: the storage (or elastic) modulus G′ and the loss (or viscous) modulus G″ (Schwab et al., 2020). The storage modulus, G′, relates to the amount...
